Top Santee SC Hotels

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Carolyn Osborne

Updated: 14 February 2024 · 6 min

Nestled in the center of South Carolina, the charming town of Santee offers a tranquil retreat for travelers looking to escape the hustle and bustle of city life. With its serene lakes, lush golf courses, and friendly locals, Santee SC provides the perfect backdrop for a relaxing getaway. For those planning a visit, choosing the right accommodation is crucial, and Santee SC hotels come with promises of comfort, convenience, and warm Southern hospitality.

Selecting a hotel in Santee SC isn’t just about finding a place to rest your head; it's about enhancing your travel experience. Whether you're here for the renowned fishing, golfing, or simply to enjoy the natural beauty, there's a hotel to match every desire and budget. From luxury resorts with top-notch amenities to cozy, budget-friendly inns that make you feel right at home, Santee SC hotels cater to a variety of preferences, ensuring your stay is as delightful as the picturesque surroundings.

In addition to providing a comfortable base for your adventures, many Santee SC hotels also offer insightful recommendations on local attractions and eateries, allowing you to dive deeper into the essence of this quaint town. Imagine waking up to a breathtaking lake view, savoring a hearty breakfast before heading out to explore, and then returning to a warm, welcoming room after a day full of discovery. This article aims to guide you through the best hotel options in Santee SC, ensuring your visit is nothing short of unforgettable.
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Our Top 10

(Sorted by rating & number of reviews)

1. Baymont By Wyndham Santee Motel
2. Comfort Inn & Suites Santee
3. Fairfield Inn & Suites Santee
4. Best Western Plus Santee Inn
5. Red Roof Inn Santee
6. Super 8 By Wyndham Santee Hotel
7. Carolina Bea Hive Villa
8. Club Wyndham Lake Marion
9. Econo Lodge Santee
10. Hampton Inn Santee-I-95

Luxury and Comfort: Premier Santee SC Hotels

Check Availability

Santee
Mar 12, 2026 - Mar 13, 2026

Baymont By Wyndham Santee Motel

7.4

Good

(930 Reviews)

+ 56 photos
Families looking for a comfortable and convenient stay in Santee will appreciate the Baymont by Wyndham Santee. This hotel welcomes guests with cozy, pet-friendly rooms featuring essential amenities such as free WiFi and flat-screen TVs. A complimentary breakfast provides a great start to the day, while the outdoor pool is a hit with both kids and adults looking to unwind or play. Situated near golf courses, Lake Marion, and local dining options, the Baymont by Wyndham ensures families have easy access to entertainment and exploration. Its blend of home-like comforts and friendly service makes this one of the most recommended Santee SC hotels for families.
Address: 249 Britain Street
Rating: Good 7.4 (930 Reviews)
Rooms: 58
Price: From 69$

Comfort Inn & Suites Santee

7.4

Good

(311 Reviews)

+ 113 photos
The Comfort Inn & Suites Santee provides an ideal home base for families exploring the charms of Santee. This hotel prides itself on its spacious rooms and suites, equipped with cozy beds and modern amenities like microwaves and refrigerators, ensuring a comfortable stay for the whole family. A complimentary hot breakfast offers a variety of options to please every palate, while the outdoor pool invites guests to make a splash and relax under the sun. Additionally, its proximity to Lake Marion and local parks makes it easy for families to embark on outdoor adventures. The Comfort Inn & Suites stands out as a family-friendly hotel in Santee SC, offering the perfect blend of convenience and comfort.
Address: 221 Britain Street
Rating: Good 7.4 (311 Reviews)
Rooms: 61
Price: From 117$

Family-Friendly Stays: Welcoming Santee SC Hotels

Families planning a vacation in Santee will find a selection of hotels that not only welcome children but also provide the amenities and services necessary to ensure a comfortable and memorable stay for all ages. These hotels understand the needs of traveling families, offering spacious rooms, kid-friendly meals, and convenient access to local attractions. From swimming pools that promise hours of fun to complimentary breakfasts that fuel the day's adventures, these family-friendly hotels in Santee make vacationing with loved ones a breeze. Here, the focus is on creating joyful family moments against the scenic backdrop of Santee SC.

Fairfield Inn & Suites Santee

9.2

Good

(313 Reviews)

+ 14 photos
At the Fairfield Inn & Suites Santee, families are greeted with bright, cheerful accommodations that promise a stress-free and enjoyable stay. Every room is designed with comfort in mind, offering plush bedding, free high-speed internet, and ergonomic workspaces for those who need it. The hotel boasts an indoor pool, perfect for year-round entertainment, and a fitness center for health-conscious guests. A complimentary breakfast with a variety of choices ensures a hearty start to the day, while the hotel’s location makes it easy to access Santee’s kid-friendly attractions. The Fairfield Inn & Suites Santee emerges as a top choice for families, combining the convenience of modern amenities with the natural beauty of Santee SC.
Address: 9074 Old Number Six Highway
Rating: Good 9.2 (313 Reviews)
Rooms: 91
Price: From 154$

Best Western Plus Santee Inn

8.4

Good

(739 Reviews)

+ 92 photos
Embrace the warmth and comfort of the Best Western Plus Santee Inn, a favorite among travelers seeking both relaxation and adventure. With its charming decor, this hotel offers spacious rooms equipped with all the modern conveniences, including microwaves, refrigerators, and free WiFi. The outdoor pool and hot tub are ideal for unwinding after a day on the road or on the greens, while the complimentary full breakfast ensures a great start to your day. Located conveniently near Santee's golf courses and Lake Marion, guests can easily indulge in the best outdoor activities. The blend of Southern hospitality and comfortable luxury makes this Santee SC hotel a standout choice.
Address: 9059 Old Number Six Highway
Rating: Good 8.4 (739 Reviews)
Rooms: 102
Price: From 106$

Budget-Friendly Options: Affordable Santee SC Hotels

For travelers looking to maximize their experience in Santee without stretching their budget, there are several hotels offering excellent value for your money. These budget-friendly options do not compromise on comfort or convenience, providing clean, comfortable rooms, friendly service, and easy access to Santee's attractions. With amenities such as free breakfast, Wi-Fi, and swimming pools, these hotels ensure a pleasant stay while helping you save on accommodation expenses. Here we highlight hotels in Santee that prove affordability doesn't mean lowering your standards.

Red Roof Inn Santee

6.7

Good

(246 Reviews)

+ 52 photos
For budget-minded travelers who don't want to compromise on modern comforts, the Red Roof Inn Santee is an excellent choice. This hotel offers clean, contemporary rooms with free Wi-Fi, ensuring guests stay connected. The outdoor swimming pool is a bonus, providing a welcome relief on warm days. Located conveniently close to I-95, guests have easy access to Santee's attractions, dining, and shopping. With its combination of affordability, comfort, and location, the Red Roof Inn Santee is a standout among budget-friendly Santee SC hotels.
Address: 9091 Old Highway 6
Rating: Good 6.7 (246 Reviews)
Rooms: 40
Price: From 90$

Super 8 By Wyndham Santee Hotel

6.2

Good

(175 Reviews)

+ 19 photos
The Super 8 by Wyndham Santee is another excellent option for travelers seeking affordability without sacrificing quality. Offering a complimentary breakfast, free Wi-Fi, and pet-friendly rooms, it caters to a wide range of needs. Guests can enjoy a comfortable night's sleep in the well-equipped rooms and start their day with a variety of breakfast options. Its location makes it easy to explore local attractions, including golf courses and Lake Marion. For those traveling on a budget, the Super 8 by Wyndham Santee ensures a pleasant and cost-effective stay in Santee SC.
Address: 9125 Old Highway 6
Rating: Good 6.2 (175 Reviews)
Rooms: 41
Price: From 56$

Unique Stays: Distinctive Santee SC Hotels

While some travelers seek traditional accommodations, others look for hotels with a unique charm or distinctive feature that can turn a simple stay into a memorable experience. Santee does not disappoint, offering unique stays that reflect the area's personality and natural beauty. From waterfront properties offering stunning views and direct lake access to quaint accommodations with local character, these hotels promise a stay that’s as unique as your travels.

Carolina Bea Hive Villa

10.0

Good

(2 Reviews)

+ 14 photos
For a truly unique stay blending comfort with a touch of local charm, the Carolina Bea Hive invites travelers to a cozy, intimate setting. Though not a traditional hotel, this private accommodation stands out for its blend of home comforts and access to Santee's natural landscapes. Ideal for smaller groups or families, guests can enjoy a personalized experience, with amenities that ensure both comfort and a sense of belonging. The proximity to Lake Marion and local activities makes Carolina Bea Hive a charming base for exploring the wonders of Santee SC, offering a distinctive alternative to conventional hotels.
Address: 367 Neds Cove
Rating: Good 10.0 (2 Reviews)

Club Wyndham Lake Marion

+ 10 photos
Club Wyndham Lake Marion provides a unique stay experience with its picturesque lakefront setting and array of family-friendly activities. Guests can choose from spacious one, two, or three-bedroom condos, each fully equipped with kitchens, living rooms, and private balconies. With amenities such as outdoor pools, a fitness center, and access to Lake Marion for boating and fishing, this resort promises both relaxation and adventure. The property’s serene location and resort-style features make Club Wyndham Lake Marion a sought-after destination for those seeking a distinctive Santee SC hotel stay.
Address: 401 Bass Drive
Price: From 169$

Econo Lodge Santee

5.7

Good

(53 Reviews)

+ 81 photos
The Econo Lodge Santee offers guests a comfortable and affordable stay, making it an ideal choice for budget-conscious travelers. Guests can enjoy free continental breakfast, Wi-Fi, and access to an outdoor pool – a refreshing way to unwind after a day of explorations. Each room is equipped with essentials such as microwaves and refrigerators, adding to the convenience. Located near several dining options and Lake Marion, this hotel provides an excellent base for visitors wanting to explore the area without breaking the bank. The Econo Lodge Santee stands as a testament to accessible comfort and hospitality within the Santee SC hotels spectrum.
Address: 9112 Old Number 6 Hwy
Rating: Good 5.7 (53 Reviews)
Rooms: 37
Price: From 57$

Hampton Inn Santee-I-95

9.2

Good

(545 Reviews)

+ 109 photos
The Hampton Inn Santee-I-95 stands as a beacon of comfort and accessibility in the center of Santee. This hotel goes beyond the standard offerings with its well-appointed rooms featuring plush bedding, free high-speed internet, and HDTVs for a touch of luxury. Guests can start their day with a complimentary hot breakfast before exploring local attractions or conducting business. An outdoor pool provides the perfect respite from the South Carolina heat, while the fitness center caters to those wanting to stay active. For convenience, meeting facilities and a business center are available, making this hotel a top choice for both leisure and business travelers seeking quality accommodation in Santee SC.
Address: 9060 Old Number Six Highway
Rating: Good 9.2 (545 Reviews)
Rooms: 81
Price: From 115$

Holiday Inn Santee, An Ihg Hotel

7.9

Good

(103 Reviews)

+ 76 photos
At the Holiday Inn Santee, an IHG Hotel, guests are treated to an upscale experience that highlights the beauty and leisure of Santee. This hotel distinguishes itself with refined rooms offering comfortable bedding, workspace, and room service, ensuring a restful stay. An on-site restaurant and bar present exquisite dining options, while the outdoor pool and fitness center offer leisure and wellness opportunities. Positioned strategically for easy access to local attractions, this hotel also provides ample event and meeting spaces, suited for both social gatherings and corporate events. The Holiday Inn Santee encapsulates the essence of luxury and comfort within the Santee SC hotels category, offering a premier choice for visitors.
Address: 139 Bradford Boulevard
Rating: Good 7.9 (103 Reviews)
Rooms: 84
Price: From 139$